|- Patient, Population, or Problem||What are the most important characteristics of the patient? How would you describe a group of patients similar to yours?|
|- Intervention, Exposure, Prognostic Factor||What main intervention, prognostic factor, or exposure are you considering? What do you want to do for the patient (prescribe a drug, order a test, etc.)?|
|- Comparison||What is the main alternative to compare with the intervention?|
|- Outcome||What do you hope to accomplish, measure, improve, or affect?|
|- Time Factor, Type of Study (optional)||How would you categorize this question? What would be the best study design to answer this question?|
For more information visit PICO: Cochrane Library Tutorial.